Nadia El Fekih
Faten Zéglaoui
Asma Sioud
Bécima Fazaa
Monia Kharfi
Sadok Gaigi
Ridha Kamoun


Introduction :Bullosis diabeticorum is a rare characteristic complication of diabetes mellitus; it affects 0.5% of diabetics. Bullosis diabeticorum is a manifestation of complicate and longstanding diabetes mellitus. The aim : of our study was to describe
particularities of diabetes in patients suffering of this disease.
Patients and method : We have led a retrospective study covering a 5 year-period (January 2001- December 2007) in the dermatology department of the Charles Nicolle’s hospital in Tunisia. We selected for this study all cases of bullosis diabeticorum.
Results : During the studied period, 10 cases have been collected. They were in all cases about complicate and long-standing diabetes. Bullosis diabeticorum has a favourable outcome in all cases with symptomatic treatment
Comments : The different cases of bullosis diabeticorum reported in our series were associated to complicate diabetes mellitus what lets suggest that vascular deteriorations led to cutaneous fragility responsible for the skin cleavage.


Diabetes, bullosis diabeticorum



  1. Aye M, Masson E.A. Dermatological care of the diabetic foot. Am J Clin Dermatol 2002; 3, 7: 463-74
  2. Basarab T, Munn S.E, McGrath J, Russell Jones R. Bullosis diabeticorum. A case report and literature review. Clin Exp Dermatol 1995; 20: 218-20
  3. Mazer J.M, Belaïch S Bullose idiopathique des diabétiques. Ann Dermatol Venereol 1987; 114: 593-7.
  4. Anand K.P, Kashyap A.S. Bullosis diabeticorum. Postgrad Med J 2004; 80: 354
  5. Diris N, Colomb M, Leymarie F, Durlach V, Caron J, Bernard P. Dermatoses non infectieuses au cours du diabète sucré. Ann Dermatol Venereol 2003; 130; 1009-14
  6. Toonstra J. Bullosis diabeticorum. J Am Acad Dermatol 1985; 13: 789-805.
  7. Bernstein J.E, Levine L.E, Medenica M.M, Yung C.W, Soltani K. Reduced threshold to suction-induced blister formation in insuliodependent diabetics. J Am Acad Dermatol 1983; 8: 790-1.
  8. Derighetti M, Hohl D, Krayenbuhl B.H, Panizzon R.G. Bullosis diabeticorum in a newly discovered type diabetes mellitus. Dermatology 2000; 200: 366-7.
  9. Fung M.A, Murphy M.J, Hoss DM, Berke A, Grant-Kels J.M. The sensivity and specificity of “caterpillar bodies” in the differential diagnosis of subepidermal blistering disorders. Am J Dermatopathol 2003; 25, 4: 287-90
  10. Ourseler J.R, Goldbum O.M. Blistering eruption in a diabetic. Bullosis diabeticorum. Arch Dermatol 1991; 127: 247-50.
  11. Benamor S, Senet P, Chosidow O. Manifestations cutanéomuqueuses du diabète. Encycl Méd Chir (Editions Scientifiques et Médicales Elsevier SAS, Paris), Dermatologie, 98-866-A-10, 2002, 6p.