Pulmonary metastases revealing choriocarcinoma


Leila El Fekih
Hela Hassene
Soraya Fenniche
Hajer Ben Abdelghaffar
Dalenda Belhabib
Mohamed Lamine Megdiche


Background: Uterin choriocarcinoma is a trophoblastic tumour characterised by high metastasis potential. Pleuropulmonary metastasis can reveal rarely the neoplasm.
Aim : Repport a new case.
Case report: We report the case of a 31 years- old woman, with no pathological antecedent, admitted in our department for thoracic pain and haemoptysis occurring two months after delivery of a did in child-birth. Chest X ray and thoracic CT scan showed several bilateral opacities.
 A diagnosis of metastatic choriocarcinoma was confirmed by plasmatic level of ß human chorionic gonadotrophin (ß HCG) superior to 4000 UI/ml. Gynaecological exam revealed latero-uterine mass. Abdomino-pelvien ultra sound and CT scan showed tissular latero uterine and hepatic masses. Brain CT scan had been normal.
Patient did after 3 cures of chemotherapy because of acute respiratory failure caused by massive pulmonary embolism.
Conclusion: Diagnosis of choriocarcinoma must be evocated in front of several pulmonary opacities occurring in genital activity women and necessities the dosage of level of ßHCG.


Choriocarcinoma, Lung, Metastasis, Chemotherapy



  1. Malbran CHE, Aupecle M.H, Chaboche Ch, Theodore Ch. Choriocarcinome materno-f?tal après accouchement normal :J Gyn Obst Biol Reprod.1993;33:789-792.
  2. Chang WC, Hung YC, Shen HP. Choriocarcinoma with pulmonary metastasis J. Reprod Med. 2007 ; 52 : 450-23
  3. Fatnassi R, Slimène F, Dhouibi S, Karray T, Nagra R. Choriocarcinome utérin révélé par des métastases pulmonaires. La Tunisie Médicale. 2005 : 645-647
  4. Guerin IC, Touraine R, Biron P, Pasquier J. Métastases pulmonaires révélatrices d'un chorio carcinome placentaire. Rev Mal Resp. 1986; 4: 401-6.
  5. Libshitz HT,Baber CE,Hammond CB,FOCOGM D. The pulmonary metastasis of choriocarcinoma.Obstet gynecol 1997, 412-415.
  6. Philippe E, Boue J, Boue A. Les maladies trophoblastiques gestationnelles. Ann Anat Path 1980; 1:13-38.
  7. Maigre M, Thomas B, Camp G, Theodore CH. Choriocarcinome uterin révélé par des métastases pulmonaires. Sem Hop (Paris) 1992; 68,: 1408-1411.
  8. Droz JP, Lhomme C.Les tumeurs trophoblastiques gestationnelles. Rev Prat 1992; 42:7.
  9. Golfier F,Raudrant T,Frappar JL et all .Les moles hydatiformes et les tumeurs trophoblastiques :Conduite à tenir pratique :mise à jour en gynecologie et obstetrique :VIGOT 2003 : 53-100.