Efficacy of metformin in the treatment of diabetes mellitus complicating thalassemia major.


N Dhouib
Z Turki
F Mellouli
M Ouederni
S Yahiaoui
S Nagi
C Ben Slama
N Bejaoui



  1. Farmaki K, Angelopoulous N, Anagnostopoulous G, Gotsis E, Rombopoulos G, Tolis G. Effect of enhanced iron chelation therapy on glucose metabolism in patients with ‚-thalassaemia major. Br J Haematol. 2006; 134: 438-444.
  2. Cario H, Holl RW, Debatin KM, Kohne E. Insulin sensitivity and beta-cell secretion in thalassemia major with secondary haemochromatosis: assessment by oral glucose tolerance test. Eur J Pediatr. 2003;16: 139-146.
  3. Chern JP, Lin KH, Lu MY, Lin D, Lin KS, Chen JD, Fu CC. Abnormal glucose tolerance in transfusion-dependent beta thalassemic patients. Diabetes care. 2001; 24: 850-854.
  4. Hundal RS, Inzucchi SE. Metformin: new understandings, new uses. Drugs.2003; 63: 1879-1894.
  5. Kosecki SM, Rodgers PT, Adams MB .Glycaemic monitoring in diabetics with sickle cell plus beta-thalassemia haemoglobinopathy. Ann Pharmacother.2005; 39: 1557-1560.