Cerebral venous thrombosis after first Methotrexate administration by lumbar puncture in a patient with large B cell lymphoma


Aicha Ben Kahla
Olfa Kassar
Khadija Moalla
Yosra Fakhfakh
Yosr Hentati
Moez Elloumi


Cerebral venous thrombosis is a rare consequence of lumbar punctures for intrathecal therapy. We report a patient treated for diffuse large B cell lymphoma with cerebral venous thrombosis after intrathecal Methotrexate administration. In this patient, intrathecal treatment was discontinued and he was successfully treated with high-dose low-molecular-weight heparin subcutaneously.

Haematologist must be aware about neurological symptoms of cerebral venous thrombosis as a complication of lumbar puncture especially among patients with high coagulopathy state.

If neurological symptom occurs, patient should be referred early to neurologist to avoid fatal outcome and neurological deficit.


Cerebral venous thrombosis, diffuse large B cell lymphoma, intrathecal Methotrexate, lumbar puncture



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