Hyperimmunoglobulinemia E and hereditary immune deficiencies


Ilham Fadil
Fatima Ailal
Vivien Beziat
Jean Laurent Casanova
Bertrand Boisson
Ahmed Aziz Bousfiha


The detection of a high serum immunoglobulin E (IgE) level is first suggestive of allergy, atopy or parasitosis. However, some very high values can be a sign of more severe diseases. We propose a diagnostic strategy based on clinical and biological data to identify the various hereditary immune diseases that also present with abnormally high serum IgE levels.


Hyperimmunoglobulinemia E , Hereditary immune deficiencies , HyperIgE syndromes , Primary immune deficiencies.



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