Particularities of Sjögren Syndrome in elderly

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Published Jun 28, 2024
https://doi.org/10.62438/tunismed.v102i7.4876
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Vol. 102 No. 7 (2024): Tunis Med jul 2024

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Fatma Said
Department of Internal Medicine, La Rabta Hospital. Tunis El Manar University, Faculty of Medicine, Tunis. Tunisia
Ines Naceur
Department of Internal Medicine, La Rabta Hospital. Tunis El Manar University, Faculty of Medicine, Tunis. Tunisia
Tayssir Ben Achour
Department of Internal Medicine, La Rabta Hospital. Tunis El Manar University, Faculty of Medicine, Tunis. Tunisia
Maysam Jeridi
Department of Internal Medicine, La Rabta Hospital. Tunis El Manar University, Faculty of Medicine, Tunis. Tunisia
Imed Ben Ghorbel
Department of Internal Medicine, La Rabta Hospital. Tunis El Manar University, Faculty of Medicine, Tunis. Tunisia
Monia Smiti
Department of Internal Medicine, La Rabta Hospital. University of Tunis El Manar, Faculty of Medicine of Tunis. Tunisia

Abstract

Background: Diagnosis of Sjögren syndrome (SS) can be difficult in the elderly in whom sicca syndrome can be related to senescence, comorbidities or to iatrogenesis.


Methods: We performed a retrospective study including of SS patients records (AECG criteria) in the internal medicine departement, La Rabta Hospital over 18 years. Epidemiological, clinical, biological and therapeutic features of elderly patients (EP) and young patients(YP) were compared


Results: A total of 323 patients with SS were enrolled, 35 were over 65 years of age (33 females/2 males). The mean age at disease onset was 68.8±4.4 years. Comparative analysis showed that SS diagnosis was made earlier in elderly (p=0.02). Fatigue was more frequent in elderly (p<0.01). Positivity of anti-SSA was more frequent in YP (p=0.04). Anti-malarial agents were less prescribed in elderly (p=0.03). There was no significant differences concerning the other clinical features, laboratory findings, treatment and outcomes.


Conclusion: The SS in elderly seems not to be a distinct subset of disease. However, treatment and follow-up of elderly patients with SS must obey to closer attention considering their vulnerability and the complexity of their management.

Keywords:

Sjögren syndrome, elderly

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